We also found that AGAP2-AS1 promoted colon cancer cell proliferation, migration and invasion through the Hippo signaling. Conclusion: Upregulated expression of AGAP2-AS1 promoted proliferation, invasion and migration in colon cancer by forming a negative feedback loop with LINC-PINT.

Browse information about AGAP2-AS1 (ENSG00000255737) covering related drugs, protein structure, pathways, genetic associations, orthologs, RNA expression and cancer biomarkers.

If available, associations are ranked by standardized value The lncRNA AGAP2-AS1 is located on a cytogenetic band in chromosome 12q14.1, which contains 1567 nucleotides (12q14.1 is the gene symbol of AGAP2-AS1 in HUGO Gene Nomenclature Committee 48633, entrez gene: 100130776, Ensemble: ENSG00000255737). Long non-coding RNA (lncRNA) AGAP2-AS1 acts as an oncogene in several types of cancers. However, the role and mechanism of AGAP2-AS1 in papillary thyroid carcinoma (PTC) remain unclear. Thus, in this study, we aimed to explore the role of AGAP2-AS1 in PTC. Our results showed that AGAP2-AS1 was significantly upregulated in PTC tissues. Knockdown of AGAP2-AS1 inhibited the proliferation Therefore, si-AGAP2-AS1 1, 2 and pcDNA-AGAP2-AS1 were used for all subsequent AGAP2-AS1 knockdown or overexpression experiments.

Agap2-as1

Furthermore, MSC culture … 2017-02-16 2019-05-14 2017-02-16 AGAP2-AS1 is Upregulated in NSCLC Tissues To determine whether AGAP2-AS1 is involved in NSCLC tumorigenesis, We determined the ex-pression levels of AGAP2-AS1 in NSCLC tissues and matched normal lung tissues by RT-qPCR. As shown in Figure 1, the results showed that the me-dian expression level of AGAP2-AS1 was higher in 2016-05-19 Prostate cancer remains a significant cause of cancer-related deaths in male population. More recently, accumulating evidence continues to implicate long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs in various types of cancers, including prostate cancer. The current study aimed to elucidate the role of lncRNA AGAP2-AS1/miR-195-5p/PDZ and LIM domain 5 (PDLIM5) in prostate cancer Exploration of Serum Exosomal LncRNA TBILA and AGAP2-AS1 as Promising Biomarkers for Diagnosis of Non-Small Cell Lung Cancer . Yao Tao 1, Yuting Tang 1, Zailin Yang 2, Futao Wu 3, Lu Wang 1, Liyuan Yang 1, Li Lei 1, Yipei Jing 1, Xueke Jiang 1, Hongjun Jin 1, Yao Bai 3, Ling Zhang 1 .

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HGNC data for AGAP2-AS1. Approved symbol. AGAP2-AS1. Approved name. AGAP2 antisense RNA 1. Locus type. RNA, long non-coding. HGNC ID. HGNC:

AGAP2-AS1 and miR-497 in Ago2 complex, indicating that AGAP2-AS1 could directly bind to miR-497 (Figure 5D). These results suggest that AGAP2-AS1 interacts with miR-497. FGFR1 was targeted by miR-497 in CRC cells Furthermore, dual luciferase reporter assay showed that overexpression of AGAP2-AS1 blocked the inhibition AGAP2-AS1 promotes CCA cell proliferation in vitroandvivo.(A-B)CCK-8 assay was performed to determine the proliferation of HUCCT1 and RBE cells with si … Interestingly, AGAP2‐AS1 sponges miR‐4,668‐3p to release SRSF1 in CRC. Furthermore, in the rescue functional assay, miR‐4,668‐3p down‐regulation exacerbated the malignant behaviors of AGAP2‐AS1‐depleted CRC cells, whereas such effects were further … SP1-induced lncRNA AGAP2-AS1 expression promotes chemoresistance of breast cancer by epigenetic regulation of MyD88 Symbol: AGAP2-AS1: Name: AGAP2 antisense RNA 1: Type: other: Synonyms: AGAP2 antisense RNA 1, AGAP2-AS1, LOC100130776, PNS, PUNISHER: Species: Human (AGAP2-AS1 EG The gene AGAP2-AS1 may have Genomic and Proteomic products available from Sigma-Aldrich. 2020-06-05 Complete information for SATB2-AS1 gene (RNA Gene), SATB2 Antisense RNA 1, including: function, proteins, disorders, pathways, orthologs, and expression.

2019-05-14 · AGAP2-AS1-suppressive HCCLM3 cells that were transfected with anti-miR-16-5p were subjected to qRT-PCR for miR-16-5p. miR-16-5p restoration abrogated the effects of AGAP2-AS1 overexpression on cell proliferation (h), migration (i), invasion (j), EMT process (l) and apoptosis (k) of Hep3B cells. miR-16-5p knockdown reversed the suppressive effects of AGAP2-AS1 knockdown in HCCLM3 cells (h-l).

High AGAP2-AS1 expression may predict a poor prognosis in GBM patients. SP1 induced AGAP2-AS1 plays an important role in tumorigenesis. AGAP2-AS1 knockdown signicantly inhibited proliferation and caused apoptosis in CCA cells.

In vitro loss- and gain-of-function assays AGAP2-AS1 dysregulation and characterize the mech-anism by which AGAP2-AS1 regulates its targets in the GC cells. Taken together, the obtained findings may provide new insights into the critical role of the lncRNA AGAP2-AS1 in human GC tumorigenesis and progression.
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The expression of AGAP2-AS1, miR-195-5p, and FOSL1 in tumor tissues isolated from EC patients and EC … 2021-02-15 AGAP2‐AS1 can be activated by transcript factor FOXP1. A and B, FOXP1 expression level at protein and RNA level by Western blotting and qPCR, respectively, when HTR‐8/SVneo cells were transfected with FOXP1‐specific siRNAs. The AGAP2‐AS1 expression level was tested by qPCR after treated with siRNAs against AGAP2‐AS1 (B, right panels). Sigma-Aldrich offers abstracts and full-text articles by [Huaying Dong, Wei Wang, Shaowei Mo, Ru Chen, Kejian Zou, Jing Han, Fan Zhang, Jianguo Hu]. Functionally, AGAP2-AS1 knockdown inhibited glioma cell proliferation and accelerated glioma cell apoptosis.

The function of AGAP2-AS1-miR-15a/b-5p-HDGF axis was confirmed by performing rescue assays. 16 AGAP2-AS1 Silencer Select Pre-designed, Validated, and Custom siRNA in Standard, HPLC, and In-vivo Ready Purities. AGAP2-AS1 inhibits CCA cell proliferation, colony formation, and promotes apoptosis.
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AGAP2-AS1 was up-regulated and associated with poor prognosis in GBM. Knockdown of AGAP2 -AS1 suppressed proliferation and invasion, and facilitated apoptosis in GBM cells . To explore the functional relevance of AGAP2AS1 in - GBM cells, we interfered endogenous AGAP2-AS1 expression in U87/MG and U251/MG cells by

Stunning AGAP2-AS1 (AGAP2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AGAP2-AS1 include Glioblastoma and High Grade Glioma. Additional gene information for AGAP2-AS1 Gene HGNC (48633) Results: AGAP2-AS1 was upregulated and transcriptionally induced by SP1 in breast cancer.

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188, ARHGEF7-AS1, 0.49, 3.55, 0.00, 0.00, NPC, lncRNA 655, AGAP2-AS1, 65.32, 4.22, 4.00, 11.00, 6.7, 2.0E-02, 16.330, 2.0E-02, 1.1, 5.0E-02, 2.8, 0.0E+00

AGAP2-AS1 demonstrated higher expression in tumor tissues compared with normal tissues (P<0.001; Fig. 1A). Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test. Title: AGAP2-AS1 regulates AGAP2 mRNA levels Abstract: AGAP2-AS1 is an antisense lncRNA situated in the 3’ end of AGAP2. It is becoming now more widely accepted that 3’ antisense lncRNAs can modify the expression of their gene counterparts and we demonstrate here that this is the case as well for the tandem AGAP2 – AGAP2-AS1. AGAP2-AS1 was up-regulated and associated with poor prognosis in GBM. Knockdown of AGAP2 -AS1 suppressed proliferation and invasion, and facilitated apoptosis in GBM cells .